Amiodarone is class III anti arrhythmic agent which is useful in treating patient with atrial flutter, ventricular ectopic beat, atrial fibrillation and tachyarrhythmia.
Amiodarone will block the beta adrenoceptors and block sodium ion channel. Amiodarone will also block the potassium ion channel in the cell membrane. Amiodarone will lead to an increase in the duration of the action potential while delaying the repolarization. This will finally lead to an increase in the refractory period. The half life of amiodarone may last for several weeks.
Amiodarone is a long acting drugs which will bind to the tissue extensively. The common side effects of amiodarone may include thyroid disorders, liver damage/ hepatotoxicity, photosensitivity skin rashes, pulmonary fibrosis and torades de pointes.