Abiblo Pharmacology - Lidocaine
Lidocaine is also known as class Ib anti arrhythmic agent. Lidocaine is useful in treating patient with digoxin induced arrhythmia and treating and prevention of ventricular fibrillation due to / post infarction. Lidocaine is mostly given intravenously with very high first pass metabolism. Lidocaine may metabolized by cytochrome P450 with half life of 2 hours.
Lidocaine will block the opening of the sodium ion channel and lead to inactivation of the sodium ion channel in the cell membrane. Blockage of the sodium ion channel may lead to reduction the rate of depolarisation of the phase 0 which cause the slow AV conduction and increase in the refractory period. Lidocaine is associated with use dependence. Lidocaine is more likely to react on the depolarised damaged tissue.
The common side effects of lidocaine may include convulsion, drowsiness and tremor.
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